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Publications

Highlighted Work

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Experimental modeling supports a role for MyBP-HL as a novel myofilament component in arrhythmia and dilated cardiomyopathy

Partial and complete loss of myosin binding protein H-like cause cardiac conduction defects

Contractile dysfunction in the cardiac conduction system

Barefield Lab Publications

Cizauskas HE, Burnham HV, Panni A, Pena A, Alvarez-Arce A, Davis MT, Araujo KN, Delligatti C, Edassery S, Kirk JA, Arora R, Barefield DY. Proteolytic degradation of atrial sarcomere proteins underlies contractile defects in atrial fibrillation. In Press. Am J Physiol Heart Circ Physiol. 2024

Burnham HV, Cizauskas HE, Barefield DY. Fine tuning contractility: atrial sarcomere function in health and disease. 1;326(3) Am J Physiol Heart Circ Physiol. 2024

Barefield DY, Tonino P, Woulfe KC, Rahmanseresht S, O'Leary TS, Burnham HV, Wasserstrom JA, Kirk JA, Previs MJ, Granzier HL, McNally EM. Myosin-binding protein H-like regulates myosin-binding protein distribution and function in atrial cardiomyocytes. 19;120(51) Proc Natl Acad Sci USA. 2023

Barefield DY. Is Haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations? 3;155(4) J Gen Physiol. 2023

Barefield DY, Araujo KN, Alvarez-Arce A. Mechanisms of Sarcomere Protein Mutation-Induced Cardiomyopathies. 6;169:28-40. Curr Cardiol Rep. 2023

Barefield DY. et al. Partial and complete loss of myosin binding protein H-like cause cardiac conduction defects. 6;169:28-40. J Mol Cell Cardiol . 2022

Prior Publications

Salamone IM. et al. Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms. 15;132(6). J Clin Invest . 2022

Demonbreun AR. et al. Anti-latent TGFβ binding protein 4 antibody improves muscle function and reduces muscle fibrosis in muscular dystrophy. 8;13(610). Sci Transl Med . 2021

Barefield DY. et al. Loss of dysferlin or myoferlin results in differential defects in excitation-contraction coupling in mouse skeletal muscle. 5;11(1):15865. Sci Rep . 2021

Gacita AM. et al. Altered Enhancer and Promoter Usage Leads to Differential Gene Expression in the Normal and Failed Human Heart. Oct;13(10):e006926. Circ Heart Fail . 2020.

Demonbreun AR. et al. A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping. Nov 4;13(2). Dis Model Mech . 2019.

Demonbreun AR. et al. Recombinant annexin A6 promotes membrane repair and protects against muscle injury. Nov 1;129(11):4657-4670. J Clin Invest . 2019.

Aubert G. et al. Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective. Apr 29;4(2):251-268. JACC Basic Transl Sci . 2019

Kuster DWD. et al. Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy. Cardiovasc Res.1;115(14):1986-1997. Cardiovasc Res. 2019

Barefield DY. et al. Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. Apr;129:236-246. J Mol Cell Cardiol . 2019.

Kim EY. et al. Distinct pathological signatures in human cellular models of myotonic dystrophy subtypes. 21;4(6):e122686. JCI Insight . 2019

Barefield DY. Garbinicius JF. Highlights from the American Heart Association's Basic Cardiovascular Science 2018 Scientific Sessions. Nov 20;7(22):e011097. J Am Heart Assoc . 2018

Ramratnam M. et al. Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function. Jul 4;4(7):e00677. Heliyon . 2018

Barefield DY. It Takes a Village to Train a Scientist. Sep 29;121(8):908-909. Circ Res . 2017

Grimes KM et al. The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent. 469:1603-1613. Pflugers Arch . 2017

Barefield DY. et al. Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament Component in Arrhythmia and Dilated Cardiomyopathy. Oct 17;136(16):1477-1491. Circulation . 2017.

Quattrocelli M. et al. Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy. Jun 1;127(6):2418-2432. J Clin Invest . 2017.

Barefield DY, et al. High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant. Nov;7(6):303. J Mol Biomark Diagn . 2016.

Demonbreun AR. et al. An actin-dependent annexin complex mediates plasma membrane repair in muscle. Jun 20;213(6):705-18. J Cell Biol . 2016.

Demonbreun AR. et al. Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal Disruption. 186(6):1610-22. Am J Pathol . 2016

Taylor EN. et al. Alterations in Multi‐Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein‐C. Mar 15;5(3):e002836. J Am Heart Assoc . 2016

Lynch TL. et al. Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation. Oxid Med Cell Longev . 2015

Gao QQ. et al. Reengineering a transmembrane protein to treat muscular dystrophy using exon skipping. Nov 2;125(11):4186-95. J Clin Invest . 2015.

McNally EM, Barefield DY, Puckelwartz MJ. The genetic landscape of cardiomyopathy and its role in heart failure. 3;21(2):174-182. Cell Metab . 2015.

Barefield DY. et al. Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice. Feb;79:234-43. J Mol Cell Cardiol . 2015.

Hoffmann J. et al. Sham Surgery and Inter-Individual Heterogeneity Are Major Determinants of Monocyte Subset Kinetics in a Mouse Model of Myocardial Infarction. 3;9(6):e98456. PLoS One . 2014.

Wang L. et al. Phosphorylation of cMyBP-C Affects Contractile Mechanisms in a Site-specific Manner. Mar 4;106(5):1112-22. Biophys J . 2014.

Barefield DY. et al. Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy. Mar 306(6):H807-15. Am J Physiol Heart Circ Physiol . 2014.

Kuster Diederik WD, et al. A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay. Aug 8;(78):50786. J Vis Exp . 2013.

Verma SK, et al. Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB. Jul 24;126(4):418-29. Circulation . 2012

Govindan S, et al. Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction. Jan;52(1):154-64. J Mol Cell Cardiol . 2012

Sadayappan S. et al. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Jul 8;109(2):141-50. Circ Res . 2011.

Barefield DY, Sadayappan S. Phosphorylation and function of cardiac myosin binding protein-C in health and disease. May;48(5):866-75. J Mol Cell Cardiol . 2010.

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