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Publications

Barefield Lab Publications

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Barefield DY, Araujo KN, Alvarez-Arce A. Mechanisms of Sarcomere Protein Mutation-Induced Cardiomyopathies. 6;169:28-40. Curr Cardiol Rep. 2023

Barefield DY. et al. Partial and complete loss of myosin binding protein H-like cause cardiac conduction defects. 6;169:28-40. J Mol Cell Cardiol . 2022

Prior Publications

Salamone IM. et al. Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms. 15;132(6). J Clin Invest . 2022

Demonbreun AR. et al. Anti-latent TGFβ binding protein 4 antibody improves muscle function and reduces muscle fibrosis in muscular dystrophy. 8;13(610). Sci Transl Med . 2021

Barefield DY. et al. Loss of dysferlin or myoferlin results in differential defects in excitation-contraction coupling in mouse skeletal muscle.  5;11(1):15865. Sci Rep . 2021

Gacita AM. et al. Altered Enhancer and Promoter Usage Leads to Differential Gene Expression in the Normal and Failed Human Heart. Oct;13(10):e006926. Circ Heart Fail . 2020. 

Demonbreun AR. et al. A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping. Nov 4;13(2). Dis Model Mech . 2019. 

Demonbreun AR. et al. Recombinant annexin A6 promotes membrane repair and protects against muscle injury. Nov 1;129(11):4657-4670. J Clin Invest . 2019.

Aubert G. et al. Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective. Apr 29;4(2):251-268. JACC Basic Transl Sci . 2019

Kuster DWD. et al. Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy. Cardiovasc Res.1;115(14):1986-1997. Cardiovasc Res. 2019

Barefield DY. et al. Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. Apr;129:236-246. J Mol Cell Cardiol . 2019.

Kim EY. et al. Distinct pathological signatures in human cellular models of myotonic dystrophy subtypes. 21;4(6):e122686. JCI Insight . 2019

Barefield DY. Garbinicius JF. Highlights from the American Heart Association's Basic Cardiovascular Science 2018 Scientific Sessions. Nov 20;7(22):e011097. J Am Heart Assoc . 2018

Ramratnam M. et al. Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function. Jul 4;4(7):e00677. Heliyon . 2018

Barefield DY. It Takes a Village to Train a Scientist. Sep 29;121(8):908-909. Circ Res . 2017

Grimes KM et al. The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent. 469:1603-1613. Pflugers Arch . 2017

Barefield DY. et al. Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament Component in Arrhythmia and Dilated Cardiomyopathy. Oct 17;136(16):1477-1491. Circulation . 2017.

Quattrocelli M. et al. Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy. Jun 1;127(6):2418-2432. J Clin Invest . 2017. 

Barefield DY, et al. High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant. Nov;7(6):303. J Mol Biomark Diagn . 2016. 

Demonbreun AR. et al. An actin-dependent annexin complex mediates plasma membrane repair in muscle. Jun 20;213(6):705-18. J Cell Biol . 2016. 

Demonbreun AR. et al. Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal Disruption. 186(6):1610-22. Am J Pathol . 2016

Taylor EN. et al. Alterations in Multi‐Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein‐C. Mar 15;5(3):e002836. J Am Heart Assoc . 2016

Lynch TL. et al. Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation. Oxid Med Cell Longev . 2015

Gao QQ. et al. Reengineering a transmembrane protein to treat muscular dystrophy using exon skipping. Nov 2;125(11):4186-95. J Clin Invest . 2015.  

McNally EM, Barefield DY, Puckelwartz MJ. The genetic landscape of cardiomyopathy and its role in heart failure. 3;21(2):174-182. Cell Metab . 2015. 

Barefield DY. et al. Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.  Feb;79:234-43. J Mol Cell Cardiol . 2015. 

Hoffmann J. et al. Sham Surgery and Inter-Individual Heterogeneity Are Major Determinants of Monocyte Subset Kinetics in a Mouse Model of Myocardial Infarction. 3;9(6):e98456. PLoS One . 2014. 

Wang L. et al. Phosphorylation of cMyBP-C Affects Contractile Mechanisms in a Site-specific Manner. Mar 4;106(5):1112-22. Biophys J . 2014. 

Barefield DY. et al. Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy. Mar 306(6):H807-15. Am J Physiol Heart Circ Physiol . 2014. 

Kuster Diederik WD, et al. A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay. Aug 8;(78):50786. J Vis Exp . 2013. 

Verma SK, et al. Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB. Jul 24;126(4):418-29. Circulation . 2012

Govindan S, et al. Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction. Jan;52(1):154-64. J Mol Cell Cardiol . 2012

Sadayappan S. et al. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Jul 8;109(2):141-50. Circ Res . 2011. 

Barefield DY, Sadayappan S. Phosphorylation and function of cardiac myosin binding protein-C in health and disease. May;48(5):866-75. J Mol Cell Cardiol . 2010. 

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